1666. It is a year after plague has devastated England. Young widow Cecilia Thorowgood is a prisoner, trapped and isolated within the cavernous London townhouse of her older sister. At the mercy of a legion of doctors who fail to cure her grief with their impatient scalpels, Cecilia...

1666. It is a year after plague has devastated England. Young widow Cecilia Thorowgood is a prisoner, trapped and isolated within the cavernous London townhouse of her older sister. At the mercy of a legion of doctors who fail to cure her grief with their impatient scalpels, Cecilia shows no signs of improvement. Soon, her sister makes a decision borne of desperation: she hires a new physician, someone known for more unusual methods. But he is a foreigner. A Jew. And despite his attempts to save Cecilia, he knows he cannot quell the storm of grief that rages within her. There is no easy cure for melancholy.

David Mendes fled Portugal to seek a new life in London, where he could practice his faith openly and leave the past behind. Still reeling from the loss of his beloved friend, struggling with his religion and his past, David finds himself in this foreign land, free and safe, but incapable of happiness--caring not even for himself, but only for his ailing father. The security he has found in London threatens to disappear when he meets Cecilia, and he finds himself torn between his duty to medicine and the beating of his own heart. He is the only one who can see her pain; the glimmers of light she emits, even in her gloom, are enough to make him believe once more in love.

Facing seemingly insurmountable challenges, David and Cecilia must endure prejudice, heartbreak, and calamity before they can be together. A Great Fire is coming--and with the city in flames around them, love has never felt so impossible.